Hot config for people looking to spend big

If you are thinking of upgrading or buying a new computer, have a load of cash, and want to be future proof for a while (read >= 5 years) then this configuration would suit you:

Motherboard:EVGA Classified Super Record 2 (SR-2) about AUD1000
Processors: 2x Intel Xeon X5680 Gulftown, 3.33GHz, Six Core hyper-threaded about AUD2000 each
RAM: 12 hand-picked, hand-tested DIMMs, 48GB of ultra-high capacity at 1,900MHz, CL8 G.Skill Ripjaws
Power Supply: Thermaltake ToughPower 1500W PSU about AUD500
GPUs: 4x ATI Radeon HD5870 2GB OR 2x ATI Radeon HD5970 2GB (optional 1x Nvidia GTX480 (PhysX + 3D)) roughly AUD2000

And that does not even include the case (which will have to specifically support that over-sized HPTX motherboard) nor its cooling.
For a case (that does not exist yet), have a look at Mick64's dream case on extreme system or this Lian Li case.

And if you do build something like that, don't forget to post pictures and brag about it in forums, you deserve it :)